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Tuesday, December 31, 2019

The world's first contraceptive vaccine for men

The world's first contraceptive vaccine for men

For a long time, there were only two methods of contraception that were directly related to men. They could either wear a condom or undergo a surgery called ischemia, which closes the drains through which the sperm reaches the penis. Contraceptive pills and gels for men are still being developed.
The world's first contraceptive vaccine for men
The world's first contraceptive vaccine for men

However, a contraceptive vaccine for men is being introduced soon in India. Will this be the contraceptive method that will be successful for men?

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Developed by 78-year-old biomedical engineer Sujay Gaha, based in Delhi, the vaccine is a single-shot vaccine that is injected into the drains that carry the sperm to the penis. The vaccine in combination with local anesthesia is not hormonal, and researchers claim that the vaccine will be effective for 13 years.

After years of testing on humans, this drug called Rizig is now ready to be introduced in the market. The vaccine is a vaccine that neutralizes sperm. The effects of this medicine are also reversible. However, the second part of the procedure under which the effects of this drug can be reversed has not yet been tested on humans, although it has been successful in animals.

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And like other methods, contraceptive injections will not be able to protect against sexually transmitted diseases.

"This contraceptive injection made for men will be world-class," says RS Sharma, a specialist in the Indian Council of Medical Research in Delhi and the lead researcher on the drug. It is safe and effective and will work for a long time. We hope to allow production in the near future.

But is it really a reversible contraceptive drug? A lot of questions are being raised in this regard.

Some scientists say that 'risag' is an alternative to the surgical prosthesis, whose efficacy is not entirely denied by Indian researchers.

Michael Skinner, a reproductive specialist at Washington State University, told me, 'As a reversible contraceptive drug, it needs further review. For now, this is just a method of sterilization. The injection must be proof of its return before it can be used as a contraceptive drug.

Dr. Gaha agrees. "We will not claim to be able to return it yet, but I am sure we will be able to do so after testing humans. Right now, we call this drug a good solution for the Victim. It will leave no traumatic effects on the men and there will be no sign of surgery. '

This year, Dr. Sharma published the results of clinical trials of the drug. The vaccine was administered to 139 married men with at least two children under the age of 41 and monitored for six months. Of these, 133 men's wives did not become pregnant after sex. In six cases where the drug did not work, leakage was attributed to vaccine syringes or sperm transplants.

However, this seemingly low failure rate is also important for Dr. Stephanie Page, a researcher at Washington University. She says' this rate and the potential adverse effects of this drug may not be much different than viscemi. There is a need for more data in this regard. '

Professor Page says that although research on this drug has been positive so far, he believes the number of participants in the trial is 139, and that six months is still insufficient.

She says 'this medicine is definitely the next step but it cannot be called a game-changer.'

Indian researchers say Rizgh has passed three stages of experiments on humans. And the experiments have been performed on more than 500 volunteers using the best procedures made nationwide since 1990.

More than two dozen drug-related research has been cited in three decades to clarify the efficacy of this drug in preventing pregnancy.

Researchers say the injection will be available at a lower cost and will be effective in the long run to prevent pregnancy. He also said that the volunteers did not complain of libido disappearance or any other side effect.

India's drug regulators are expected to give the green light for the production and sale of the drug soon, and it is more likely that the Indian government will do the work itself.

It is time for men to adopt effective contraceptive methods as well. For decades, women have been carrying the burden of an unplanned pregnancy.

Researchers say pregnancy and birth risks remain high. Therefore, the need for women to develop safe and effective contraceptive drugs is higher than for men. Scientific and social efforts have focused more on contraceptive methods for women.

Nearly 60 years after the first contraceptive pill was available in the United States, women today rely on more than a dozen methods to prevent unplanned pregnancies, including pills, patches, injections, implants, rings, and cups. Included.

The international interest in rigs is also high.

Dr. Gaha licensed the drug to the Parsimus Foundation, a nonprofit organization based in the American city of Berkeley, to introduce it to the United States, and another contraceptive drug, Vessel Jill, is already in clinical trials. Simultaneously, clinical trials of this drug are ongoing in six European countries. With the help of a bill from the Bill and Melinda Gates Foundation, Dr. Gaha is developing a drug for women that is a vaccine and stops the pregnancy.

So will men now play their part in this process?

In masculine societies like India, the use of contraceptives is less in men. According to official data, 90% of married couples do not use condoms. Men's vaccination rates are extremely low. After all, sterilization is the most popular method of contraception.

However, researchers believe that attitudes are changing worldwide.
Dr. Page says' times and attitudes are changing worldwide. One of the reasons men are less likely to have a role in contraception is that they have very few ways to do so. The goal of this field is to give men options in this regard. Only then will men take responsibility for their shoulders from their peers.
It is time now that Rising becomes a successful drug that men desperately need.

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